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Related post: products are available for distribution under an IND as well as for in vitro use. The supply of Antigens E and Ra3 has almost been depleted; distribution of these items has been stopped. The remaining supplies are being held to be compared with the new lots being produced by the Rockefeller University. Production of Antigen E has been completed and is now being tested. As soon as the test results have been analyzed, the material will be processed and packaged. Production of Ra3 is scheduled for completion in September. C. Immunological Reagents and Resources The contract awarded in FY 1978 to Flow Stromectol 3 Mg Laboratories for the maintenance and breeding of rabbits of known genotype for use in immunological studies was terminated for the convenience of the Government effective March 19, 1982. This contract activity was merged with another facility (Spring Valley Laboratories) which maintains another rabbit colony. These facilities provide reference quantities of reagents and limited numbers of rabbits to responsible investigators doing immunological studies. During this period, 2 shipments of rabbit antisera and 7 shipments consisting of 49 live rabbits were made to various investigators. D. Microbiological Reagents Under a procurement contract with the American Type Culture Collection, arrangements were made to process the immune ascitic fluids of African swine fever, rift valley fever, African horsesickness and bovine ephemeral fever, prepared under an interagency agreement with the Plum Island Animal Disease Center. The four ascitic fluids will be placed in the Catalog as soon as the final test data have been reported. The Enterovirus Typing Pools A thru H originally prepared in 1971 have been distributed widely and after 11 years use, the supply of these pools is almost exhausted. A request from WHO for the pools had to be denied because of the low level of material available. Additional bulk materials are available to have another batch prepared; however, certain preliminary work would be required; i.e., testing and evaluation, processing and packaging, and retesting of final packaged product. In view of the fact that the Institute has assigned a low priority to maintaining reagents primarily for surveillance and epidemic investigations and also because of budgetary reductions, the American Type Culture Collection (ATCC) was asked if they would be in a position to assume responsibility for preparing a new batch if the Institute provided the bulk material. The ATCC has responded that they would be interested in preparing new pools but would have to have additional financial support in order to do so. The WHO has been contacted to determine if they would be willing to contribute funds for this project. 15-2 E. Research Resources - Research Reagents While responsibility for Stromectol Price the actual production of reagents is with the various Institute program areas, RRS has continued to sponsor certain service-type contracts which serve the needs of the various program elements. Upon notification of any problem from investigators using any item distributed by this office, arrangements are made to have the product tested by a competent laboratory. The intensive work .of prior years has resulted in the completion of work on the enterovirus, adenovirus, rhinovirus, myxovirus and the agents and antigens of hepatitis A and B. In most cases, seed virus preparations and corresponding antisera are now available for most of the viruses of public health interest. The reagents which have resulted from the various projects have been most useful, particularly the hemagglutinins, neuraminidases, ribonucleoproteins and the influenza viruses of man and animals. After a category of reagents has become established, and the area of research that it supports is well defined, it is of questionable value for RRS to continue storing and distributing that category of reagents for a prolonged period of time. During FY 1975, it was determined that four viral reagent groups fell into that category. The RRS therefore, entered into a five-year contractual arrangement with the American Type Culture Collection (ATCC) to transfer the enterovirus, adenovirus, rhinovirus and arbovirus reagent collections to the ATCC whose prime function is to store and distribute these type of reagents. Additional reagents are currently being identified for possible transfer to ATCC. F. Processing and Distribution In addition to the various program elements detailed above, the RRS also distributes coronavi ruses, herpes viruses, interferons, mycoplasmas and reoviruses. During this year a blanket type procurement agreement has been in effect for the processing and packaging of various items. To date four arbovirus ascitic fluids, one penicillin lot and complement component C3 have been assigned to completion under this arrangement with the American Type Culture Collection. The RRS reagent collection consists of over 350 individual reagents. The repository and distribution contract remains at Flow Laboratories, McLean, Virginia. A tabular record of distribution by the facility since FY 1974 follows: 15-3 TABLE VI DISTRIBUTION OF VIRAL, MYCOPLASMAL, AND ALLERGEN REAGENTS Total ampoules & vials Fiscal Year Total Transactions distributed 1974 1975 1976 1976 (TQ) 1977 1978
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