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Related post: products are available for distribution under an IND as well as for
in vitro use. The supply of Antigens E and Ra3 has almost been depleted;
distribution of these items has been stopped. The remaining supplies
are being held to be compared with the new lots being produced by the
Rockefeller University. Production of Antigen E has been completed
and is now being tested. As soon as the test results have been
analyzed, the material will be processed and packaged. Production of
Ra3 is scheduled for completion in September.
C. Immunological Reagents and Resources
The contract awarded in FY 1978 to Flow Stromectol 3 Mg Laboratories for the maintenance
and breeding of rabbits of known genotype for use in immunological
studies was terminated for the convenience of the Government effective
March 19, 1982. This contract activity was merged with another
facility (Spring Valley Laboratories) which maintains another rabbit
colony. These facilities provide reference quantities of reagents
and limited numbers of rabbits to responsible investigators doing
immunological studies. During this period, 2 shipments of rabbit
antisera and 7 shipments consisting of 49 live rabbits were made to
D. Microbiological Reagents
Under a procurement contract with the American Type Culture Collection,
arrangements were made to process the immune ascitic fluids of African
swine fever, rift valley fever, African horsesickness and bovine
ephemeral fever, prepared under an interagency agreement with the Plum
Island Animal Disease Center. The four ascitic fluids will be placed
in the Catalog as soon as the final test data have been reported.
The Enterovirus Typing Pools A thru H originally prepared in 1971 have
been distributed widely and after 11 years use, the supply of these
pools is almost exhausted. A request from WHO for the pools had to
be denied because of the low level of material available. Additional
bulk materials are available to have another batch prepared; however,
certain preliminary work would be required; i.e., testing and evaluation,
processing and packaging, and retesting of final packaged product.
In view of the fact that the Institute has assigned a low priority to
maintaining reagents primarily for surveillance and epidemic investigations
and also because of budgetary reductions, the American Type Culture
Collection (ATCC) was asked if they would be in a position to assume
responsibility for preparing a new batch if the Institute provided the
bulk material. The ATCC has responded that they would be interested
in preparing new pools but would have to have additional financial
support in order to do so. The WHO has been contacted to determine if
they would be willing to contribute funds for this project.
E. Research Resources - Research Reagents
While responsibility for Stromectol Price the actual production of reagents is with the
various Institute program areas, RRS has continued to sponsor certain
service-type contracts which serve the needs of the various program
elements. Upon notification of any problem from investigators using
any item distributed by this office, arrangements are made to have the
product tested by a competent laboratory.
The intensive work .of prior years has resulted in the completion of
work on the enterovirus, adenovirus, rhinovirus, myxovirus and the
agents and antigens of hepatitis A and B. In most cases, seed virus
preparations and corresponding antisera are now available for most
of the viruses of public health interest. The reagents which have
resulted from the various projects have been most useful, particularly
the hemagglutinins, neuraminidases, ribonucleoproteins and the
influenza viruses of man and animals.
After a category of reagents has become established, and the area
of research that it supports is well defined, it is of questionable
value for RRS to continue storing and distributing that category of
reagents for a prolonged period of time. During FY 1975, it was
determined that four viral reagent groups fell into that category.
The RRS therefore, entered into a five-year contractual arrangement
with the American Type Culture Collection (ATCC) to transfer the
enterovirus, adenovirus, rhinovirus and arbovirus reagent collections
to the ATCC whose prime function is to store and distribute these
type of reagents. Additional reagents are currently being identified
for possible transfer to ATCC.
F. Processing and Distribution
In addition to the various program elements detailed above, the RRS
also distributes coronavi ruses, herpes viruses, interferons, mycoplasmas
During this year a blanket type procurement agreement has been in
effect for the processing and packaging of various items. To date
four arbovirus ascitic fluids, one penicillin lot and complement
component C3 have been assigned to completion under this arrangement
with the American Type Culture Collection.
The RRS reagent collection consists of over 350 individual reagents.
The repository and distribution contract remains at Flow Laboratories,
McLean, Virginia. A tabular record of distribution by the facility
since FY 1974 follows:
DISTRIBUTION OF VIRAL, MYCOPLASMAL,
AND ALLERGEN REAGENTS
Total ampoules & vials
Fiscal Year Total Transactions distributed
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